Proyecto Orinoco is a broad initiative to preserve, study, and promote the cultural heritage of Venezuela and its indigenous populations. The result of some fifty years of rigorous collecting, Proyecto Orinoco documents more than 2,000 ethnographic objects from twelve distinct societies. It also contains a vast archive of travel material from explorations in Southern Venezuela, including more than 300,000 photographs.

Guided by a commitment to make these cultures known to a wider public, the Fundación Cisneros has initiated an ongoing traveling exhibition of selections from the collection, and published the first general-audience book about the peoples of Southern Venezuela. Currently available in Spanish, English, and German, the exhibition catalogue Orinoco-Parima, Indigenous Societies of Venezuela contains extensive information about the twelve ethnic groups native to the Orinoco River basin and the extraordinary objects they create.

To encourage global awareness of and respect for the cultures of the region, the Fundación Cisneros launched Orinoco Online, an award-winning multilingual resource featuring highlights from the collection, a searchable database, in-depth articles on the indigenous groups represented in the collection, a multimedia glossary, and an interactive map of Venezuela.

One of the core cultural initiatives of the Fundación Cisneros is a wide-ranging program in visual arts education and awareness based on the Colección Cisneros. The mission of this program is to collect, preserve, study, and exhibit the Colección's extensive artworks and related archives, which consist primarily of modern and contemporary art, with an emphasis on Latin America. The Colección includes Colonial Latin American art, international decorative arts, and a selection of Latin American landscapes from the seventeenth to the early twentieth century, executed by both local artists and those who traveled to the continent from North America and Europe. Through exhibitions, a dynamic lending program, publications, arts education programs, and online access, the program works to heighten the appreciation of the diversity, quality, and range of art from Latin America.

The Colección supports arts education in Caracas schools through the Programa de Pensamiento Visual (PPV). Developed by The Museum of Modern Art in New York (MoMA) and adapted for Venezuelan schoolchildren with the help of educators from MoMA and The Galeria de Arte Nacional in Caracas, PPV uses artworks from all three collections to help children develop critical visual-thinking skills.

In an effort to broaden awareness of Latin American art at the curatorial level, the Patricia Cisneros Travel Fund for Latin America enables curators from MoMA to travel to Latin America. In addition, in 1999, the Fundación Cisneros created The Cisneros Fellowship, supporting Latin American students in the two-year post-graduate curatorial studies course at Bard College in New York.

The Colección also publishes a series of catalogues and books that highlight aspects of the Colección and Latin American art and are distributed throughout Latin America and the United States.

The Centro Mozarteum is dedicated to the professional advancement of young musicians from Venezuela; offering the Venezuelan public opportunities to experience a wide range of classical music; and raising international awareness of the excellence of Venezuelan composers and musicians. Thanks to this program, more than 200 young musicians have attended courses in the best musical centers in Europe, the United States, and Latin America; and numerous internationally acclaimed orchestras, conductors, and opera and ballet companies have performed throughout Venezuela. Other programs include master classes with internationally recognized musicians, the publication of compact discs featuring outstanding Venezuelan artists, artist exchange programs, and a resource center that maintains a library of music and recorded material. Currently, the Centro Mozarteum is working to establish a school for the study of violin and viola for talented young Venezuelan musicians, primarily from low-income backgrounds.

The Centro Mozarteum has received the support and recognition of international cultural institutions and private enterprises.